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Neutron reflectometry and NMR spectroscopy of full-length Bcl-2 protein reveal its membrane localization and conformation

Authors: Ameeq Ul Mushtaq, Jörgen Ådén, Luke A Clifton, Hanna Wacklin-Knecht, Mario Campana, Artur P G Dingeldein, Cecilia Persson, Tobias Sparrman, Gerhard Gröbner

Journal: Commun Biol

PubMed ID: 33907308

Doi: 10.1038/s42003-021-02032-1

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Regulation of the Dimerization and Activity of SARS-CoV-2 Main Protease through Reversible Glutathionylation of Cysteine 300

Authors: David A Davis, Haydar Bulut, Prabha Shrestha, Amulya Yaparla, Hannah K Jaeger, Shin-Ichiro Hattori, Paul Wingfield, Hiroaki Mitsuya, Robert Yarchoan

Journal: biorxiv

PubMed ID: 33851157

Doi: 10.1101/2021.04.09.439169

Products & Services: Recombinant Proteins

Chronic Administrations of Guanfacine on Mesocortical Catecholaminergic and Thalamocortical Glutamatergic Transmissions

Authors: Kouji Fukuyama, Tomosuke Nakano, Takashi Shiroyama, Motohiro Okada

Journal: Int J Mol Sci

PubMed ID: 33923533

Doi: 10.3390/ijms22084122

Products & Services: Proteins, Expression, Isolation and Analysis

Molecular properties of human guanylate cyclase-activating protein 2 (GCAP2) and its retinal dystrophy-associated variant G157R

Authors: Anna Avesani, Valerio Marino, Serena Zanzoni, Karl-Wilhelm Koch, Daniele Dell'Orco

Journal: J Biol Chem

PubMed ID: 33812995

Doi: 10.1016/j.jbc.2021.100619

Products & Services: Mammalian Expression

LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

Authors: Kuan-Yu Lai, Sébastien R G Galan, Yibo Zeng, Tianhui Hina Zhou, Chang He, Ritu Raj, Jitka Riedl, Shi Liu, K Phin Chooi, Neha Garg, Min Zeng, Lyn H Jones, Graham J Hutchings, Shabaz Mohammed, Satish K Nair, Jie Chen, Benjamin G Davis, Wilfred A van der Donk

Journal: Cell

PubMed ID: 33932340

Doi: 10.1016/j.cell.2021.04.001

Products & Services: Plasmid DNA Preparation

Phase separation of p53 precedes aggregation and is affected by oncogenic mutations and ligands

Authors: Elaine C Petronilho, Murilo M Pedrote, Mayra A Marques, Yulli M Passos, Michelle F Mota, Benjamin Jakobus, Gileno Dos Santos de Sousa, Filipe Pereira da Costa, Adriani L Felix, Giulia D S Ferretti, Fernando P Almeida, Yraima Cordeiro, Tuane C R G Vieira, Guilherme A P de Oliveira, Jerson L Silva

Journal: Chem Sci

PubMed ID: 34163823

Doi: 10.1039/d1sc01739j

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An engineered ligand trap inhibits leukemia inhibitory factor as pancreatic cancer treatment strategy

Authors: Sean A Hunter, Brianna J McIntosh, Yu Shi, R Andres Parra Sperberg, Chie Funatogawa, Louai Labanieh, Erin Soon, Hannah C Wastyk, Nishant Mehta, Catherine Carter, Tony Hunter, Jennifer R Cochran

Journal: Commun Biol

PubMed ID: 33846527

Doi: 10.1038/s42003-021-01928-2

Products & Services: Proteins, Expression, Isolation and Analysis

Role of Small Envelope Protein in Sustaining the Intracellular and Extracellular Levels of Hepatitis B Virus Large and Middle Envelope Proteins

Authors: Jing Zhang, Yongxiang Wang, Shuwen Fu, Quan Yuan, Qianru Wang, Ningshao Xia, Yumei Wen, Jisu Li, Shuping Tong

Journal: Viruses

PubMed ID: 33918367

Doi: 10.3390/v13040613

Products & Services: Proteins, Expression, Isolation and Analysis

Adipocyte-secreted microvesicle-derived miR-148a regulates adipogenic and osteogenic differentiation by targeting Wnt5a/Ror2 pathway

Authors: De-Yu Duan, Jing Tang, Hong-Tao Tian, Yang-Yang Shi, Jie Jia