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From the cover: roles of mmu_piR_003399 in microcystin-leucine arginine-induced reproductive toxicity in the spermatogonial cells and testis

Toxicological Sciences, . 2018; 
Ling Zhang†‡, Xiannan Meng†‡, Zou Xiang§ , Dongmei Li*†‡, Xiaodong Han*†‡
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Gene Synthesis The dual-luciferase reporter assay system was purchased from Promega (Madison, WI). SYBR GreenER qRT-PCR kit and lipofectamine 2000 were purchased from Invitrogen (Shanghai, China). qRT supermix for qRT-PCR was obtained from Vazyme (Jiangsu, China). Stem-loop RT primer and primer pairs were purchased from Genscript (Jiangsu, China) (Table S1 and S2). Get A Quote

摘要

Conclusion: The ISG15 pathway contributes to PDAC by increasing cell growth and the tumorigenic potential of pancreatic cancer cells. Ultimately, strategies to target the ISG13 pathway may lead to improved survival for patients diagnosed with PDAC.

关键词

microcystin-leucine arginine, piRNA, mouse, cyclin-dependent kinase 6, serum, plasma
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