Alzheimer's disease (AD) is characterized by physiologically endogenous proteins amyloid beta (Aβ) and tau undergoing a conformational change and accumulating as soluble oligomers and insoluble aggregates. Tau and Aβ soluble oligomers， which contain extensive β-sheet secondary structure， are thought to be the most toxic forms. The objective of this study was to determine the ability of TWF9， an anti-β-sheet conformation antibody (aβComAb)， to selectively recognize pathological Aβ and phosphorylated tau in AD human tissue compared with cognitively normal age-matched controls and to improve the performance of old 3xTg-AD mice with advanced pathology in behavioral testing after acute treatment with T... More