Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate， a bisphosphonate containing nitrogen (N-BP)， is a potent inhibitor of blood stage Plasmodium. Here， we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate， suggesting that this enzyme is an important target， and bisphosphonate analogues can be used as potential antimalarial drugs.