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Novel Human NK Cell Line Carrying CAR Targeting EGFRvIII Induces Antitumor Effects in Glioblastoma Cells.

Anticancer Res.. 2018-09; 
MurakamiToshiharu，NakazawaTsutomu，NatsumeAtsushi，NishimuraFumihiko，NakamuraMitsutoshi，MatsudaRyosuke，OmotoKoji，TanakaYoshitaka，ShidaYouichi，ParkYoung-Soo，MotoyamaYasushi，NakagawaIchiro，YamadaShuichi，TamuraKentaro，TakeshimaYasuhiro，TakamuraYoshiaki，WakabayashiToshihiko，NakaseHiro
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Gene Synthesis … was subsequently cloned (33). The scFv portion in pELNS-SS1CD28r1BBZeta was replaced with the cDNA for 3C10 scFV by gene synthesis (Genscript, Piscataway, NJ) to create pELNS-3C10-CAR. Production of vesicular … Get A Quote

摘要

Natural killer (NK) cells are considered potential antitumor effector cells. The aim of this study was to establish a novel type of a chimeric antigen receptor (CAR) NK cell line (CAR-KHYG-1) specific for epidermal growth factor receptor variant III (EGFRvIII)-expressing tumors and investigate the anti-tumor activity of EGFRvIII-specific-CAR-KHYG-1 (EvCAR-KHYG-1).

关键词

Chimeric antigen receptor，epidermal growth factor receptor variant III，glioblastoma，natural killer c
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