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Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939‒Mediated Transcriptional Repression of Bcl-xL.

Cancer Res Treat. 2018-07; 
CuiChunhui，ZhaiDuanyang，CaiLianxu，DuanQiaobin，XieLang，YuJin
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Gene Synthesis … HEIH, respectively. The pcDNA3.1-HEIH and pSPT19-HEIH with mutations in miR-939 binding sites was synthesized by GenScript (Nanjing, China) and termed pcDNA3.1-HEIH-mut and pSPT19-HEIH-mut, respectively. Bcl … Get A Quote

摘要

Studies have found that long noncoding RNA HEIH (lncRNA-HEIH) is upregulated and facilitates hepatocellular carcinoma tumor growth. However， its clinical significances， roles， and action mechanism in colorectal cancer (CRC) remains unidentified.

关键词

Bcl-xL， Colorectal neoplasms， NF-κB， Tumorigenesis， miR-939，Long noncoding
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