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Development and characterization of serotype-specific monoclonal antibodies against the dengue virus-4 (DENV-4) non-structural protein (NS1).

Virol. J.. 2018-01; 
GelanewTesfaye,HunspergerEliza
Products/Services Used Details Operation
Gene Synthesis … Sequencing the antigen binding sites of MAbs. Sequencing the antigen binding sites (the variable regions of light (VL) and heavy (VH) chains) of the three MAbs were performed by customer service (GenScript, NJ, USA) in order to determine the identity of these MAbs … Get A Quote

摘要

Dengue, caused by one of the four serologically distinct dengue viruses (DENV-1 to - 4), is a mosquito-borne disease of serious global health significance. Reliable and cost-effective diagnostic tests, along with effective vaccines and vector-control strategies, are highly required to reduce dengue morbidity and mortality. Evaluation studies revealed that many commercially available NS1 antigen (Ag) tests have limited sensitivity to DENV-4 serotype compared to the other three serotypes. These studies indicated the need for development of new NS1 Ag detection test with improved sensitivity to DENV-4. An NS1 capture enzyme linked immunoassay (ELISA) specific to DENV-4 may improve the detection of DENV-4... More

关键词

Dengue virus 4,Diagnostic,Monoclonal antibody,NS1,Non-structural protein 1,flaviv