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Increased toxicity of amylin (Islet Amyloid Polypeptide) in beta cells induced by photochemical internalization.

Photodiagnosis Photodyn Ther. 2018-09; 
RinkuSingh，HalsIngrid，HøgsetAnders，GrillValdemar，GederaasOdr
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Gene Synthesis … 3. Materials and Methods. Synthetic human amylin was from Sigma-Aldrich Chemical Co. (St. Louis, MO) and rat amylin was from GenScript (Piscataway, USA). For experiments amylin was solubilized basically as described [5], details given in Supplementary information … Get A Quote

摘要

Amylin and oligomers formed from amylin are implicated in demise of beta cells in type 2 diabetes. However， whether putative toxicity is exerted intra or extracellularly is unclear. Use of photochemical internalization (PCI) technique may give clues for impact of intracellular toxicity.

关键词

Amylin，Islet amyloid polypeptide (IAPP)，Photochemical internalization (PCI)，Type 2 diabetes，meso-tetraphenylchlorin disulfonate (TPCS(
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