澳门太阳游戏城app官网入口

资源 » 参考数据库 » 客户发表文献

至今，GenScript的服务及产品已被Cell, Nature, Science, PNAS等1300多家生物医药类杂志引用近万次，处于行业领先水平。NIH、哈佛、耶鲁、斯坦福、普林斯顿、杜克大学等约400家全球著名机构使用GenScript的基因合成、多肽服务、抗体服务和蛋白服务等成功地发表科研成果，再次证明GenScript 有能力帮助业内科学家Make research easy.

Overexpression of collagen type III in injured myocardium prevents cardiac systolic dysfunction by changing the balance of collagen distribution.

J. Thorac. Cardiovasc. Surg.. 2018-07; 
UchinakaAyako，YoshidaMaho，TanakaKiyoka，HamadaYoshinosuke，MoriSeiji，MaenoYoshitaka，MiyagawaShigeru，SawaYoshiki，NagataKohzo，YamamotoHirofumi，KawaguchiNao
Products/Services Used Details Operation
Gene Synthesis … A fragment of human Col3 α1 chain (COL3a1) cDNA including a HindIII site and secretory signal sequence at the 5′ end and XbaI sites at the 3′ end (Figure 1, A and Figure E1) was synthesized by GenScript (Piscataway, NJ) … Get A Quote

摘要

Left ventricular (LV) remodeling alters the contractile and relaxation properties and induces myocardial stiffness. As LV remodeling progresses， the amount of collagen type III (Col3) is gradually decreased， being replaced by collagen type I (Col1). We evaluated whether Col3 overexpression improved cardiac function and remodeling in a rat with ischemic cardiomyopathy (ICM). We also investigated the functional motif and mechanism of thrombin-cleaved N-terminal osteopontin (N-OPN) on cardiac remodeling.

关键词

collagen type III，ischemic cardiomyopathy，remode
Article Link >