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HCV Genotype 6a Escape From and Resistance to Velpatasvir， Pibrentasvir， and Sofosbuvir in Robust Infectious Cell Culture Models.

Gastroenterology. 2018-01; 
PhamLong V，RamirezSantseharay，GottweinJudith M，FahnøeUlrik，LiYi-Ping，PedersenJannie，Bukh
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Gene Synthesis … The 3ʹUTR, including sequences of HK6a (Supplementary Results) and of H77 (the 3ʹ terminal stem-loop), 20 was synthesized by GenScript. These sequences were assembled into pHK6a 5ʹUTR-NS2 /JFH1 8 using standard cloning procedures … Get A Quote

摘要

Chronic liver diseases caused by hepatitis C virus (HCV) genotype 6 are prevalent in Asia， and millions of people require treatment with direct-acting antiviral regimens， such as NS5A inhibitor velpatasvir combined with the NS5B polymerase inhibitor sofosbuvir. We developed infectious cell culture models of HCV genotype 6a infection to study the effects of these inhibitors and the development of resistance.

关键词

DAA，Escape Variants，In Vitro System，Nucleotide An
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