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rs61991156 in miR-379 is associated with low capability of glycolysis of gastric cancer by enhanced regulation of PKM2.

Cancer Cell Int.. 2018; 
CaoNa,LiMeng,HanJun,WangYongren,WangXia
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Gene Synthesis … The construction containing different genotype of miR-379 was also synthesized and cloned into pSilence 2.1-U6. All the DNA synthesis and clones were performed in Genscript Co. (Nanjing, China). Dual-luciferase reporter assay … Get A Quote

摘要

Glycolysis is an important metabolic oncogenic change also play a pivot role in the Warburg effect. Glycolysis related gene PKM2 expressed differently individually. Presently, we sought to investigate the effect of single nucleotide polymorphism (SNP) at rs61991156 of miR-379 on gastric cancer (GC) proliferation and metabolism.

关键词

Gastric cancer,Glycolysis,PKM2,SNP,m