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MiRNA-92a protects pancreatic B-cell function by targeting KLF2 in diabetes mellitus.

Biochem. Biophys. Res. Commun.. 2018-01; 
WangWenyi,WangJian,YanMeiling,JiangJiechun,BianA
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Gene Synthesis … Pri-miR-223 and GAPHD primers for RT-PCR were from Genscript(Nanjing, China)… Get A Quote

摘要

diabetes mellitus is one of the most common metabolic diseases worldwide characterized by insulin resistance and pancreatic β cell dysfunction. miRNA plays an important role in DM. In previous studies, miRNA-92a could function as targets for innovative precision medicines to reduce T1D islet autoimmunity. However, the relationship between miRNA-92a and pancreatic β cell dysfunction remains unknown. The aim of the study was to investigate the role of miRNA-92a in pancreatic β cell dysfunction.

关键词

Apoptosis,Diabetes,KLF2,miRNA