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Hemeoxygenase-1 Suppresses IL-1β-Induced Apoptosis Through the NF-κB Pathway in Human Degenerative Nucleus Pulposus Cells.

Cell. Physiol. Biochem.. 2018; 
ZhuChaoying，JiangWei，ChengQiang，HuZhenming，Ha
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Gene Synthesis … Subsequently, qPCR was performed using Maxima SYBR-Green/ROX qPCR Master mix (Thermo Fisher Scientific, Inc.) according to the manufacturer's protocol. Primer sequences used were obtained from Genscript (Nanjing, China) … Get A Quote

摘要

Nucleus pulposus cell (NPC) apoptosis is the main factor in intervertebral disc degeneration (IDD); thus， inhibiting the excessive apoptosis of nucleus pulposus cells may be a potential way to alleviate IDD. The effect of Hemeoxygenase-1 (HO-1) on human NPC apoptosis has never been reported. Our study aimed to investigate the effect and mechanism of HO-1 on apoptosis in human degenerative NPCs.

关键词

Apoptosis，Hemeoxygenase-1，Human nucleus pulposus cells，IL-1β，NF
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