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Increased Lactate in Gastric Cancer Tumor-Infiltrating Lymphocytes Is Related to Impaired T Cell Function Due to miR-34a Deregulated Lactate Dehydrogenase A.

Cell. Physiol. Biochem.. 2018; 
PingWang, SenyanHu, LiGu, YanChen, Long L.
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Gene Synthesis … Lentiviral production and transfection. Full-length LDHA and miR-34a were synthesized by Genscript. The sequences were subcloned into pLV-His plasmid, and further packaged for lentiviral particles as previously described [13] … Get A Quote

摘要

Lactate is one of the products of glycolysis and is a hallmark of the Warburg effect. Glycolysis is found in tumor as well as immune cells. However， the effects of lactate on the function of tumor-infiltrating T cells (TILs) are rarely reported.

关键词

Cytotoxic T lymphocytes，Lactate，Lactate dehydrogenase A，Th1 cells，miR
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