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Identification of Filamin-A and-B as potential biomarkers for prostate cancer.

Future Sci.. 2016-12; 
Niven R Narain??, Anne R Diers??, Arleide Lee??, Socheata Lao??, Joyce Y Chan??, Sally Schofield??, Joe Andreazi??, Rakibou Ouro-Djobo??, Joaquin J Jimenez??, Tracey Friss??, Nikunj Tanna??, Aditee Dalvi??, Sihe Wang??, Dustin Bunch??, Yezhou Sun??, Wenfang Wu??, Khampaseuth Thapa??, Stephane Gesta??, Leonardo O Rodrigues??, Viatcheslav R Akmaev??, Vivek K Vishnudas?? & Rangaprasad Sarangarajan??.
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摘要


Aim:
A novel strategy for prostate cancer (PrCa) biomarker discovery is described.
Materials & methods:
In vitro perturbation biology, proteomics and Bayesian causal analysis identified biomarkers that were validated in in vitro models and clinical specimens.
Results:
Filamin-B (FLNB) and Keratin-19 were identified as biomarkers. Filamin-A (FLNA) was found to be causally linked to FLNB. Characterization of the biomarkers in a panel of cells revealed differential mRNA expression and regulation. Moreover, FLNA and FLNB were detected in the conditioned media of cells. Last, in patients without PrCa, FLNA and FLNB blood levels were positively correlated, while in p... More

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