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High-throughput T cell receptor engineering by functional screening identifies candidates with enhanced potency and specificity
Authors: Rodrigo Vazquez-Lombardi, Johanna S Jung, Fabrice S Schlatter, Anna Mei, Natalia Rodrigues Mantuano, Florian Bieberich, Kai-Lin Hong, Jakub Kucharczyk, Edo Kapetanovic, Erik Aznauryan, Cédric R Weber, Alfred Zippelius, Heinz Läubli, Sai T Reddy
Journal: Immunity
PubMed ID: 36174557
Doi: 10.1016/j.immuni.2022.09.004
Products & Services: Peptide Synthesis   
mRNA Treatment Rescues Niemann-Pick Disease Type C1 in Patient Fibroblasts
Authors: Denzil Furtado, Christina Cortez-Jugo, Ya Hui Hung, Ashley I Bush, Frank Caruso
Journal: Mol Pharm
PubMed ID: 36125338
Doi: 10.1021/acs.molpharmaceut.2c00463
Products & Services: GenParts™ DNA Fragments   
A humanized 4-1BB-targeting agonistic antibody exerts potent antitumor activity in colorectal cancer without systemic toxicity
Authors: Lian-Sheng Cheng, Yong-Feng Cheng, Wen-Ting Liu, Aolin Shen, Dayan Zhang, Tingjuan Xu, Wu Yin, Min Cheng, Xiaopeng Ma, Fengrong Wang, Qun Zhao, Xiaoli Zeng, Yan Zhang, Guodong Shen
Journal: J Transl Med
PubMed ID: 36076251
Doi: 10.1186/s12967-022-03619-w
Products & Services: Mammalian Expression   
H2B Lys34 Ubiquitination Induces Nucleosome Distortion to Stimulate Dot1L Activity
Authors: Huasong Ai , Maoshen Sun , Aijun Liu , Zixian Sun , Tingting Liu , Lin Cao , Lujun Liang , Qian Qu , Zichen Li , Zhiheng Deng , Zebin Tong , Guochao Chu , Xiaolin Tian , Haiteng Deng , Suwen Zhao , Jia-Bin Li , Zhiyong Lou , Lei Liu
Journal: Nat Chem Biol
PubMed ID: 35739357
Doi: 10.1038/s41589-022-01067-7
Products & Services: Gene Synthesis   
The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA–protein cross-link
Authors: Katherine A Paulin , David Cortez , Brandt F Eichman
Journal: J Biol Chem
PubMed ID: 35934051
Doi: 10.1016/j.jbc.2022.102307
Products & Services: Peptide Synthesis   
Guide RNA engineering enables efficient CRISPR editing with a miniature Syntrophomonas palmitatica Cas12f1 nuclease
Authors: Yujue Wang , Yannan Wang ， Deng Pan , Haopeng Yu , Yifei Zhang , Weizhong Chen , Fan Li , Zhaowei Wu , Quanjiang Ji
Journal: Cell Rep
PubMed ID: 36170834
Doi: doi.org/10.1016/j.celrep.2022.111418
Products & Services: PCR and Cloning   
Nilaparvata lugens salivary protein NlG14 triggers defense response in plants
Authors: Haoli Gao , Jianzheng Zou , Xumin Lin , Huihui Zhang , Na Yu , Zewen Liu
Journal: J Exp Bot
PubMed ID: 36056768
Doi: 10.1093/jxb/erac354
Products & Services: Proteins, Expression, Isolation and Analysis   
Autophagic flux restoration of senescent T cells improves antitumor activity of TCR-engineered T cells
Authors: Chaoting Zhang, Yizhe Sun, Shance Li, Luyan Shen, Xia Teng, Yefei Xiao, Ping Zhou, Zheming Lu
Journal: Clin Transl Immunology
PubMed ID: 36188121
Doi: 10.1002/cti2.1419
Products & Services: Plasmid DNA Preparation   
Proposal to Consider Chemical/Physical Microenvironment as a New Therapeutic Off-Target Approach
Authors: Alessandro Giuliani, Stefano Fais
Journal: Pharmaceutics
PubMed ID: 36297518
Doi: 10.3390/pharmaceutics14102084
Products & Services: Custom Vector Construction   
Development of a GalNAc-Tyrosine-Specific Monoclonal Antibody and Detection of Tyrosine -GalNAcylation in Numerous Human Tissues and Cell Lines
Authors: Li Xia, Tiffany R Bellomo, Ruslan Gibadullin, Molly D Congdon, Elijah F Edmondson, Mi Li, Alexander Wlodawer, Crystal Li, J Sebastian Temme, Pavan Patel, Donna Butcher, Jeffrey C Gildersleeve
Journal: J Am Chem Soc
PubMed ID: 36054098
Doi: 10.1021/jacs.2c04477
Products & Services: Mammalian Expression   
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