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Base editing of haematopoietic stem cells rescues sickle cell disease in mice

Authors: Gregory A Newby, Jonathan S Yen, Kaitly J Woodard, Thiyagaraj Mayuranathan, Cicera R Lazzarotto, Yichao Li, Heather Sheppard-Tillman, Shaina N Porter, Yu Yao, Kalin Mayberry, Kelcee A Everette, Yoonjeong Jang, Christopher J Podracky, Elizabeth Thaman, Christophe Lechauve, Akshay Sharma, Jordana M Henderson, Michelle F Richter, Kevin T Zhao, Shannon M Miller, Tina Wang, Luke W Koblan, Anton P McCaffrey, John F Tisdale, Theodosia A Kalfa, Shondra M Pruett-Miller, Shengdar Q Tsai, Mitchell J Weiss, David R Liu

Journal: Nature

PubMed ID: 34079130

Doi: 10.1038/s41586-021-03609-w

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An improved lentiviral system for efficient expression and purification of ??-defensins in mammalian cells

Authors: Shiraz Ahmed, Jiang Tao, Miaochen Wang, Yue Zhai, Wenhai Liu, Muthukumaran Jayachandran, Chen Chu, Shen Qu, Jin Zhang, Yonglian Zhang, Zhaoliang Fei

Journal: Biotechnol J

PubMed ID: 34053189

Doi: 10.1002/biot.202100023

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Gut Microbiome Directs Hepatocytes to Recruit MDSCs and Promote Cholangiocarcinoma

Authors: Zhang Q,Ma C,Duan Y,Heinrich B,Rosato U,Diggs LP,Ma L,Roy S,Fu Q,Brown ZJ,Wabitsch S,Thovarai V,Fu J,Feng D,Ruf B,Cui LL,Subramanyam V,Frank KM,Wang S,Kleiner DE,Ritz T,Rupp C,Gao B,Longerich T,Kroemer A,Wang XW,Ruchirawat M,Korangy F,Schnabl B,Trinchieri G,Greten TF

Journal: Cancer Discovery

PubMed ID: 33323397

Doi: 10.1158/2159-8290.CD-20-0304

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Lipoteichoic Acid from Activates the Complement System via C3 Induction and CD55 Inhibition

Authors: Bong Jun Jung, Hangeun Kim, Kyoung Ok Jang, Seongjae Kim, Dae Kyun Chung

Journal: Microorganisms

PubMed ID: 34074052

Doi: 10.3390/microorganisms9061135

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Specific inhibition of oncogenic RAS using cell-permeable RAS-binding domains

Authors: Teiko Komori Nomura, Kazuki Heishima, Nobuhiko Sugito, Ryota Sugawara, Hiroshi Ueda, Akao Yukihiro, Ryo Honda

Journal: Cell Chem Biol

PubMed ID: 33964212

Doi: 10.1016/j.chembiol.2021.04.013

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Propionate induces intestinal oxidative stress via Sod2 propionylation in zebrafish

Authors: Qianwen Ding, Zhen Zhang, Yu Li, Hongliang Liu, Qiang Hao, Yalin Yang, Einar Ringø, Rolf Erik Olsen, Jihong Liu Clarke, Chao Ran, Zhigang Zhou

Journal: iScience

PubMed ID: 34142031

Doi: 10.1016/j.isci.2021.102515

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PLGA-particle vaccine carrying TLR3/RIG-I ligand Riboxxim synergizes with immune checkpoint blockade for effective anti-cancer immunotherapy

Authors: Julia Koerner, Dennis Horvath, Valerie L Herrmann, Anna MacKerracher, Bruno Gander, Hideo Yagita, Jacques Rohayem, Marcus Groettrup

Journal: Nat Commun

PubMed ID: 34006895

Doi: 10.1038/s41467-021-23244-3

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Natural Endotoxemia in Dogs-A Hidden Condition That Can Be Treated with a Potential Probiotic Containing and : A Study Model

Authors: Maria-Catalina Matei, Sanda Maria Andrei, Victoria Buza, Mihai Sorin Cernea, Daria Antonia Dumitras, Daniela Neagu, Horatiu Rafa, Cristian Paul Popovici, Andrei Radu Szakacs, Adrian Catinean, Eugen Stefanut, Laura Cristina Stefanut

Journal: Animals (Basel)

PubMed ID: 34064947

Doi: 10.3390/ani11051367

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The GAR/RGG motif defines a family of nuclear alarmins

Authors: Shan Wu, Boon Heng Dennis Teo, Seng Yin Kelly Wee, Junjie Chen, Jinhua Lu

Journal: Cell Death Dis

PubMed ID: 33980825

Doi: 10.1038/s41419-021-03766-w

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Safety and Efficacy of a Phage, kpssk3, in an Model of Carbapenem-Resistant Hypermucoviscous Bacteremia

Authors: Yunlong Shi, Yuan Peng, Yixin Zhang, Yu Chen, Cheng Zhang, Xiaoqiang Luo, Yajie Chen, Zhiqiang Yuan, Jing Chen, Yali Gong