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SPTLC1 variants associated with ALS produce distinct sphingolipid signatures through impaired interaction with ORMDL proteins

Authors: Museer A Lone, Mari J Aaltonen, Aliza Zidell, Helio F Pedro, Jonas A Morales Saute, Shalett Mathew, Payam Mohassel, Carsten G Bönnemann, Eric A Shoubridge, Thorsten Hornemann

Journal: J Clin Invest

PubMed ID: 35900868

Doi: 10.1172/JCI161908

Products & Services: Proteins, Expression, Isolation and Analysis

Post-phagocytosis activation of NLRP3 inflammasome by two novel T6SS effectors

Authors: Hadar Cohen, Noam Baram, Chaya Mushka Fridman, Liat Edry-Botzer, Dor Salomon, Motti Gerlic

Journal: Elife

PubMed ID: 36155655

Doi: 10.7554/eLife.82766

Products & Services: Proteins, Expression, Isolation and Analysis

A megadiverse naïve library derived from numerous camelids for efficient and rapid development of VHH antibodies

Authors: Meiniang Wang, Likun Wei, Haitao Xiang, Bingzhao Ren, Xiaopan Liu, Lin Jiang, Naibo Yang, Jiahai Shi

Journal: Anal Biochem

PubMed ID: 36108795

Doi: 10.1016/j.ab.2022.114871

Products & Services: Proteins, Expression, Isolation and Analysis

Phosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy

Authors: Qi Yu , Xuanyunjing Gong , Yue Tong , Min Wang , Kai Duan , Xinyu Zhang , Feng Ge , Xilan Yu , Shanshan Li

Journal: NaCommunt

PubMed ID: 36167807

Doi: 10.1038/s41467-022-33423-5

Products & Services: Proteins, Expression, Isolation and Analysis

Fibrotic immune microenvironment remodeling mediates superior anti-tumor efficacy of a nano-PD-L1 trap in hepatocellular carcinoma

Authors: Xiaoyu Liu, Jingying Zhou, Haoran Wu, Shufen Chen, Lingyun Zhang, Wenshu Tang, Liang Duan, Ying Wang, Eleanor McCabe, Mengying Hu, Zhuo Yu, Hanzhuang Liu, Chung Hang Jonathan Choi, Joseph Jao-Yiu Sung, Leaf Huang, Rihe Liu, Alfred Sze-Lok Cheng

Journal: Mol Ther

PubMed ID: 36146933

Doi: 10.1016/j.ymthe.2022.09.012

Products & Services: Proteins, Expression, Isolation and Analysis

Exploring the Binding Affinity and Mechanism between ACE2 and the Trimers of Delta and Omicron Spike Proteins by Molecular Dynamics Simulation and Bioassay

Authors: Liping Zhou, Tingting Liu, Mengxia Mo, Yulong Shi, Leyun Wu, Yishui Li, Qiuping Qin, Weiliang Zhu, Chengkun Wu, Likun Gong, Zhijian Xu

Journal: J Chem Inf Model

PubMed ID: 36053674

Doi: 10.1021/acs.jcim.2c00881

Products & Services: Proteins, Expression, Isolation and Analysis

Expressing the Pro-Apoptotic Reaper Protein via Insertion into the Structural Open Reading Frame of Sindbis Virus Reduces the Ability to Infect Mosquitoes

Authors: Alexis Carpenter, Scott R Santos, Rollie J Clem

Journal: Viruses

PubMed ID: 36146841

Doi: 10.3390/v14092035

Products & Services: Proteins, Expression, Isolation and Analysis

The positive regulatory loop of TCF4N/p65 promotes glioblastoma tumourigenesis and chemosensitivity

Authors: Yaling Hu, Bo Zhang, Peihua Lu, Jingying Wang, Cheng Chen, Ying Yin, Quan Wan, Jingjing Wang, Jiantong Jiao, Xiangming Fang, Zhening Pu, Lingli Gong, Li Ji, Lingpeng Zhu, Rui Zhang, Jia Zhang, Xusheng Yang, Qing Wang, Zhaohui Huang, Jian Zou

Journal: Clin Transl Med

PubMed ID: 36116131

Doi: 10.1002/ctm2.1042

Products & Services: Proteins, Expression, Isolation and Analysis

Identification of a Potential Inhibitor (MCULE-8777613195-0-12) of New Delhi Metallo-β-Lactamase-1 (NDM-1) Using In Silico and In Vitro Approaches

Authors: Ghazala Muteeb, Md Tabish Rehman, Mohamed F AlAjmi, Mohammad Aatif, Mohd Farhan, Sheeba Shafi

Journal: Molecules

PubMed ID: 36144666

Doi: 10.3390/molecules27185930

Products & Services: Proteins, Expression, Isolation and Analysis

Context-based sensing of orthosomycin antibiotics by the translating ribosome

Authors: Kyle Mangano, James Marks, Dorota Klepacki, Chayan Kumar Saha, Gemma C Atkinson, Nora Vázquez-Laslop, Alexander S Mankin