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目录产品 » HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human
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HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human

The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.
￥3000
Z06568-100

产品简介
Species Human
Protein Construction
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer [Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLGGLLTMV peptide]
Accession # A0A140T913(HLA-A*02:01)&P61769(B2M)&CLGGLLTMV		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 52-56 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human

Immobilized HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Antibody, hFc Tag with the EC50 of 18.4 ng/ml determined by ELISA. »

HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human

The purity of HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human

HLA-A*02:01&B2M&LMP2 (CLGGLLTMV) Monomer, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background The immunoproteasome, having been linked to neurodegenerative diseases and hematological cancers, has been shown to play an important role in MHC class I antigen presentation. The development of molecular probes that selectively inhibit the major catalytic subunit, LMP2, of the immunoproteasome,LMP2-rich cancer cells compared to LMP2-deficient cancer cells are more sensitive to growth inhibition by the LMP2-specific inhibitor, implicating an important role of LMP2 in regulating cell growth of malignant tumors that highly express LMP2.
Synonyms MHC; RMF; LMP2; LMP-2; Macropain chain 7; Proteasome chain 7; PSMB9; RING12
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.