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目录产品 » Nectin-1/PVRL1/CD111, His & Avi, Human
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Nectin-1/PVRL1/CD111, His & Avi, Human

Nectins are a small family of Ca -independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that organize intercellular junctions. They are highly homologous to the human receptor for poliovirus, and as such have been alternately named poliovirus receptor-related proteins.Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Has some neurite outgrowth-promoting activity.
￥2600
Z05670-100

产品简介
Species Human
Protein Construction
Nectin-1/PVRL1/CD111 (Gln31-Thr334)_x000D_
Accession # Q15223-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 36.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 52-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
Nectin-1/PVRL1/CD111, His & Avi, Human

Immobilized Human Nectin-3, hFc Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Nectin-1/PVRL1/CD111, His & Avi, Human, His Tag with the EC50 of 60.7ng/ml determined by ELISA. »

Nectin-1/PVRL1/CD111, His & Avi, Human

Immobilized Human Nectin-4, hFc Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Nectin-1/PVRL1/CD111, His & Avi, Human, His Tag with the EC50 of 2.0μg/ml determined by ELISA. »

Nectin-1/PVRL1/CD111, His & Avi, Human

The purity of Nectin-1/PVRL1/CD111, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

Nectin-1/PVRL1/CD111, His & Avi, Human

Nectin-1/PVRL1/CD111, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

Nectin-1/PVRL1/CD111, His & Avi, Human

Human Nectin-4, hFc Tag captured on CM5 Chip via Protein A can bind Nectin-1/PVRL1/CD111, His & Avi, Human, His Tag with an affinity constant of 28.13 nM as determined in SPR assay (Biacore T200). »

Nectin-1/PVRL1/CD111, His & Avi, Human

Human Nectin-3, His Tag immobilized on CM5 Chip can bind Nectin-1/PVRL1/CD111, His & Avi, Human, His Tag with an affinity constant of 0.204 μM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Nectins are a small family of Ca -independent immunoglobulin (Ig)-like cell adhesion molecules (CAMs) that organize intercellular junctions. They are highly homologous to the human receptor for poliovirus, and as such have been alternately named poliovirus receptor-related proteins.Nectin-1 promotes cell-cell contacts by forming homophilic or heterophilic trans-dimers. Heterophilic interactions have been detected between Nectin-1 and Nectin-3 and between Nectin-1 and Nectin-4. Has some neurite outgrowth-promoting activity.
Synonyms CD111; ED4; HIgRPVRR; HVEC; MGC142031; Nectin1; PRR; PRR1; PRR1MGC16207; PVRL1; PVRR1; SK-12; PVRL1; CLPED1; HIgR; OFC7; PVRR
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.