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目录产品 » LILRB1/CD85j/ILT2, His & Avi, Human
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LILRB1/CD85j/ILT2, His & Avi, Human

LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.
￥2200
Z05593-100

产品简介
Species Human
Protein Construction
LILRB1/CD85j/ILT2 (Gly24-His458)
Accession # Q8NHL6-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 50 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 72-78 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
LILRB1/CD85j/ILT2, His & Avi, Human

Serial dilutions of LILRB1/CD85j/ILT2, His & Avi, Human Antibody were added into Biotinylated Human HLA-G Complex Tetramer, His Tag : Human LILRB1, His Tag binding reactioins. The half maximal inhibitiory concentration(IC50) is 27ng/ml. »

LILRB1/CD85j/ILT2, His & Avi, Human

Immobilized LILRB1/CD85j/ILT2, His & Avi, Human, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Anti-LILRB1 Antibody, hFc Tag with the EC50 of 5.4ng/ml determined by ELISA. »

LILRB1/CD85j/ILT2, His & Avi, Human

The purity of LILRB1/CD85j/ILT2, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

LILRB1/CD85j/ILT2, His & Avi, Human

LILRB1/CD85j/ILT2, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

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技术背景
Target Background LILRB1, also known as CD85j and ILT2, is a 110 kDa transmembrane glycoprotein in the LILR immunoregulatory protein family. Mature human LILRB1 consists of a 438 amino acid (aa) extracellular domain (ECD) with 4 tandem Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 4 inhibitory ITIM motifs.LILRB1 is a receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response.
Synonyms ILT2; ILT-2; ILT2FLJ37515; LILRB1; LIR1; MIR7; CD85J; XXbac-BCX85G21.4
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.