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目录产品 » IL-6 R alpha/CD126, His & Avi, Human
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IL-6 R alpha/CD126, His & Avi, Human

The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed.
￥3500
Z05511-100

产品简介
Species Human
Protein Construction
IL-6 R alpha/CD126 (Leu20-Pro365)
Accession # P08887-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 41.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-78 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-6 R Alpha/CD126, His & Avi, Human

Immobilized Human IL-6, No Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for IL-6 R alpha/CD126, His & Avi, Human, His Tag with the EC50 of 0.21μg/ml determined by ELISA. »

IL-6 R Alpha/CD126, His & Avi, Human

The purity of  IL-6 R alpha/CD126, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

IL-6 R Alpha/CD126, His & Avi, Human

IL-6 R alpha/CD126, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

IL-6 R Alpha/CD126, His & Avi, Human

IL-6 R alpha/CD126, His & Avi, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Human IL-6, No Tag with an affinity constant of 0.22 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background The multifunctional factor interleukin 6 (IL-6) exerts its activities through binding to a high-affinity receptor complex consisting of two membrane glycoproteins: an 80 kDa component receptor that binds IL-6 with low affinity (IL-6R alpha) and a signal-transducing component of 130 kDa (gp130) that does not bind IL-6 by itself, but is required for high-affinity binding of IL-6 by the complex. Both components of the receptor complex, IL-6R alpha and gp130 have been cloned, sequenced, and expressed.
Synonyms IL-6R subunit alpha; IL-6R-alpha; IL-6RA; IL-6R 1; IL6R; CD126; IL6RQ; gp80
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.