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目录产品 » IL-23R mFc Chimera, Human
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IL-23R mFc Chimera, Human

Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
￥3500
Z05486-100

产品简介
Species Human
Protein Construction
IL-23R (Gly24-Gly355)
Accession # Q5VWK5-1		 mFc (IgG1)
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 63.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-23R MFc Chimera, Human

lmmobilized Biotinylated IL-23R mFc Chimera, Human alpha&IL-12 beta, His-Avi Tag at 5 μg/ml (100 μl/Well) on streptavidin(5 μg/ml) precoated plate. Dose response curve for Human IL-23R, mFc Tag with the EC50 of 39.2ng/ml determined by ELISA. »

IL-23R MFc Chimera, Human

The purity of IL-23R mFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

IL-23R MFc Chimera, Human

IL-23R mFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-23R MFc Chimera, Human

IL-23R mFc Chimera, Human, mFc Tag captured on CM5 Chip via Anti-Mouse Antibody can bind Human IL-23 alpha&IL-12 beta, His-Avi Tag with an affinity constant of 11.09 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12. The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R).This receptor associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
Synonyms IBD17; IL-23 R; IL-23 receptor
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.