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目录产品 » IL-18 R1/CD218a hFc Chimera, Human
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IL-18 R1/CD218a hFc Chimera, Human

Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation.
￥1500
Z05451-100

产品简介
Species Human
Protein Construction
IL-18 R1/CD218a (Ala19-Arg329)
Accession # AAH69575.1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity IL-18 R1/CD218a hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human IL­18, No Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 62.52 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-95 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-18 R1/CD218a HFc Chimera, Human

The purity of IL-18 R1/CD218a hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

IL-18 R1/CD218a HFc Chimera, Human

IL-18 R1/CD218a hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-18 R1/CD218a HFc Chimera, Human

IL-18 R1/CD218a hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human IL-18, No Tag with an affinity constant of 0.73 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin-18 (IL-18) is a member of the interleukin-1 family of cytokines produced constitutively by different cell types and by adipose tissue. Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag plus IL-12, naïve T cells develop into IL-18 receptor (IL-18R) expressing Th1 cells, which increase IFN-γ production in response to IL-18 stimulation.
Synonyms CD218a; IL18Ra; IL18R1; IL1RRP; IL-1 R5; IL-1 Rrp; IL-18 R alpha; IL-18 R1; IL-18Ra
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.