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IL-10, His & Avi, Human

Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life.
￥4900
Z05425-100

产品简介
Species Human
Protein Construction
Avi His IL-10 (Ser19-Asn178)
Accession # P22301
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 21.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 23-25 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
IL-10, His & Avi, Human

Immobilized IL-10, His & Avi, Human, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Biotinylated Human IL-10R alpha, His Tag with the EC50 of 28.6ng/ml determined by ELISA. »

IL-10, His & Avi, Human

The purity of IL-10, His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

IL-10, His & Avi, Human

IL-10, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

IL-10, His & Avi, Human

Human IL-10R alpha, His Tag immobilized on CM5 Chip can bind IL-10, His & Avi, Human, His Tag with an affinity constant of 0.13 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Interleukin 10 (IL10) is a key anti-inflammatory cytokine that can inhibit proinflammatory responses of both innate and adaptive immune cells. An association between IL10 and intestinal mucosal homeostasis became clear with the discovery that IL10 and IL10 receptor (IL10R)-deficient mice develop spontaneous intestinal inflammation. Similarly, patients with deleterious mutations in IL10, IL10RA, or IL10RB present with severe enterocolitis within the first months of life.
Synonyms Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.