| ￥3500 | |
| Z05079-100 | |
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| Species | Human | ||||
| Protein Construction |
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| Purity | > 95% as determined by BisTris PAGE | ||||
| Endotoxin Level | Less than 1EU per μg by the LAL method. | ||||
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. | ||||
| Expression System | HEK293 | ||||
| Theoretical Molecular Weight | 111.6 kDa | ||||
| Apparent Molecular Weight | Due to glycosylation, the protein migrates to 115-130 kDa based on Bis-Tris PAGE result. | ||||
| Formulation | Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). | ||||
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water. | ||||
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |
Immobilized Beta Klotho, His, Human, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Beta Klotho Antibody1, hFc Tag with the EC50 of 23.1ng/ml determined by ELISA. »
Immobilized Beta Klotho, His, Human, His Tag at 2μg/ml (100μl/well) on the plate. Dose response curve for Anti-Beta Klotho Antibody2, hFc Tag with the EC50 of 19.5ng/ml determined by ELISA. »
Immobilized Beta Klotho, His, Human, mFc Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human Beta Klotho, His Tag with the EC50 of 0.75μg/ml determined by ELISA. »
The purity of Beta Klotho, His, Human is greater than 95% as determined by SEC-HPLC. »
Beta Klotho, His, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »
Beta Klotho, His, Human, His Tag captured on CM5 Chip via anti-His antibody can bind Human FGF21, mFc Tag with an affinity constant of 0.54nM as determined in SPR assay (Biacore T200). »
| Target Background | Beta-klotho (KLB) is a coreceptor required for endocrine fibroblast growth factor (FGF) 15/19 and FGF21 signaling in the brain. Klb is prominent within the hypothalamus, which is consistent with its metabolic functions, but diverse roles for Klb are now emerging. Central Klb expression is low but discrete and may govern FGF-targeted sites. |
| Synonyms | betaKlotho; beta-klotho; BKL; KLB; klotho beta like; Klotho beta; MGC142213;βKlotho; β-klotho; klotho β like; Klotho β |
For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.
