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目录产品 » B7-2/CD86 hFc Chimera, Human
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B7-2/CD86 hFc Chimera, Human

B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively.
￥2100
Z05054-100

产品简介
Species Human
Protein Construction
B7-2/CD86 (Leu26-Pro247)
Accession # P42081-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 52 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 75-90 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
B7-2/CD86 HFc Chimera, Human

Immobilized Human CTLA-4, His Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for B7-2/CD86 hFc Chimera, Human, hFc Tag with the EC50 of 125.7ng/ml determined by ELISA. »

B7-2/CD86 HFc Chimera, Human

The purity of B7-2/CD86 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC. »

B7-2/CD86 HFc Chimera, Human

B7-2/CD86 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background B7-1 and B7-2 are homologous costimulatory ligands expressed on the surface of antigen presenting cells (APCs). Binding of these molecules to the T cell costimulatory receptors, CD28 and CTLA-4, is essential for the activation and regulation of T cell immunity. B7-1 and B7-2 do not form hetero-oligomers, underscoring the biological relevance of dimeric and monomeric state of B7-1 and B7-2, respectively.
Synonyms CD86 molecule; CD86; B70; B7-2 antigen; B72; B7-2; BU63; FUN-1; LAB72; MGC34413; CD28LG2
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.