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目录产品 » TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human
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TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily.The expression of apoptosis-inducing TRAIL-R1 and TRAIL-R2 and of the decoy receptors TRAIL-R3 and TRAIL-R4 was systematically studied in all developmental stages of peripheral B cells isolated from the blood and secondary lymphoid organs. Expression of TRAIL-Rs is modulated along development, with highest levels observed in germinal center B cells.
￥5800
Z04632-100

产品简介
Species Human
Protein Construction
TRAIL R1/DR4/TNFRSF10A (Pro34-Asn239)
Accession # O00220		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA.Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 24.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.
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图例
TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human

Immobilized Human Trail, No Tag at 5 μg/ml (100 μl/well) on the plate. Dose response curve for TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human, His Tag with the EC50 of 0.38 μg/ml determined by ELISA. »

TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human

The purity of TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human

TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%. »

TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human

TRAIL R1/DR4/TNFRSF10A[Biotin], His & Avi, Human, His-Avi Tag immobilized on CM5 Chip can bind Human TRAIL, No Tag with an affinity constant of 0.315 nM as determined in SPR assay (Biacore T200). »

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技术背景
Target Background Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily.The expression of apoptosis-inducing TRAIL-R1 and TRAIL-R2 and of the decoy receptors TRAIL-R3 and TRAIL-R4 was systematically studied in all developmental stages of peripheral B cells isolated from the blood and secondary lymphoid organs. Expression of TRAIL-Rs is modulated along development, with highest levels observed in germinal center B cells.
Synonyms DR4; CD261; TNFRSF10A; TRAIL-R; APO2; TRAIL R1; MGC9365
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.