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CTLA-4/CD152[Biotin], His & Avi, Human

CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an 'off' switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
￥3300
Z04436-100

产品简介
Species Human
Protein Construction
CTLA-4/CD152 (Lys36-Asp161)
Accession # P16410		 His Avi
N-term C-term
Conjugate Biotin
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized CTLA-4/CD152[Biotin], His & Avi, Human at 1μg/ml (100μl/well) on the streptavidin precoated plate (5μg/ml) can bind Human B7­1, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 16.3 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.
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图例
CTLA-4/CD152[Biotin], His & Avi, Human

Immobilized CTLA-4/CD152[Biotin], His & Avi, Human His Tag at 1 μg/ml (100 μl/well) on the streptavidin precoated plate(5 μg/ml). Dose response curve for Human B7-1, hFc Tag with the EC50 of 2.4 ng/ml determined by ELISA. »

CTLA-4/CD152[Biotin], His & Avi, Human

Immobilized Anti-CTLA-4 Antibody, hFc Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for CTLA-4/CD152[Biotin], His & Avi, Human, His Tag with the EC50 of 45.7 ng/ml determined by ELISA. »

CTLA-4/CD152[Biotin], His & Avi, Human

The purity of CTLA-4/CD152[Biotin], His & Avi, Human is greater than 95% as determined by SEC-HPLC. »

CTLA-4/CD152[Biotin], His & Avi, Human

CTLA-4/CD152[Biotin], His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%. »

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技术背景
Target Background CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an 'off' switch when bound to CD80 or CD86 on the surface of antigen-presenting cells.
Synonyms CTLA4; CD152; ICOS; CELIAC3; GRD4; GSE; ALPS5; IDDM12
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.