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Staphylokinase 

Staphylokinase (SAK), a 16kDa profibrinolytic protein from the Staphylococcus aureus, has been demonstrated to induce highly fibrin-specific thrombolysis in both human plasma and in limited clinical trials. Recent studies on the thrombolytic potential of recombinant SAK in achieving early perfusion in myocardial infarction and in the dissolution of platelet-rich clot have clearly established its immense utility in clinical medicine as a thrombolytic agent and suggested that it can be developed as a potent clot-dissolving agent.
￥1260
Z02797-100

产品简介
Source E. coli
Amino Acid Sequence 00001 SSSFDKGKYK KGDDASYFEP TGPYLMVNVT GVDGKRNELL
00041 SPRYVEFPIK PGTTLTKEKI EYYVEWALDA TAYKEFRVVE
00081 LDPSAKIEVT YYDKNKKKEE TKSFPITEKG FVVPDLSEHI
00121 KNPGFNLITK VVIEKK
Appearance Sterile Filtered White lyophilized (freeze-dried) powder.
Purity > 97% by SDS-PAGE and HPLC analyses.
Biological Activity Fully biologically active when compared to standard. The specific activity determined by fibrining lysis in agarose plate is 5.0 × 104 IU/mg.
Endotoxin Level Less than 1 EU/μg of rSAK as determined by LAL method.
Molecular Weight Approximately 15.6 kDa, a single non-glycosylated polypeptide chain containing 136 amino acids.
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1 % BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 °C. Further dilutions should be made in appropriate buffered solutions.
Formulation Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4.
Storage & Stability This lyophilized preparation is stable at 2-8 °C, but should be kept at -20 °C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 °C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 °C to -70 °C. Avoid repeated freeze/thaw cycles.
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技术背景
Synonyms Staphylokinase
Target Background Staphylokinase (SAK), a 16kDa profibrinolytic protein from the Staphylococcus aureus, has been demonstrated to induce highly fibrin-specific thrombolysis in both human plasma and in limited clinical trials. Recent studies on the thrombolytic potential of recombinant SAK in achieving early perfusion in myocardial infarction and in the dissolution of platelet-rich clot have clearly established its immense utility in clinical medicine as a thrombolytic agent and suggested that it can be developed as a potent clot-dissolving agent.
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For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.