| ￥1540 | |
| RP-D00003-20 | |
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Multifunctional enzyme that has magnesium and ATP-dependent 3'-5' DNA-helicase activity on partially duplex substrates, and also 3'->5' exonuclease activity towards double-stranded (ds)DNA with a 5'-overhang. Binds preferentially to DNA substrates containing alternate secondary structures, such as replication forks and Holliday junctions. Plays a role in double-strand break repair after gamma-irradiation. |
| Synonyms | Werner syndrome helicase, RECQ3, RECQL2, RECQL3, WRN RecQ like helicase, Werner syndrome RecQ like helicase |
| Species | Homo sapiens |
| Construct | Full length |
| 外观 | Clear liquid |
| Accession# | Q14191 |
| Purity | ≥ 85% by SDS-PAGE |
| Endotoxin Level | ≤ 100 EU/mg |
| Source | Insect cell Sf9 |
| Theoretical Molecular Weight | 162 kDa |
| Tag | His tag at the C-terminus |
| Application | Drug discovery for cancer therapeutics. In vitro affinity assays, activity assays etc. |
| Formulation | Supplied as a solution of 50 mM Tris, 300 mM NaCl, 10% Glycerol, 2 mM TCEP, pH 8.0 |
| Storage & Stability | This product remains stable for up to 12 months at -80±5°C. Avoid repeated freeze-thaw cycles. |
| Note |
For
laboratory research use only. Direct human use, including taking orally and
injection and clinical use are forbidden. |
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