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Recombinant PIVKA II Antigen

Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.
询价
T06702-0.1

产品简介
Species Human
Tag His tag at the C-terminus of Recombinant PIVKA II Antigen
Purity ≥ 85% as analyzed by SDS-PAGE
Source Escherichia coli (E. coli)
Molecular Weight Predicted molecular weight: 66 kDa.
Formulation Liquid
Storage buffer 20mM PB,150 mM NaCl, PH7.2, containing 10% Glycerol, and 0.5M L-Arginine
Reactivity with GenScript MABs V06701 PIVKA II Antibody (1C5):+
V06702 PIVKA II Antibody (2D7):+
V06703 PIVKA II Antibody (6C4):+
Storage Storage at -20°C or below. Avoid repeated freezing and thawing cycles.
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图例
Recombinant PIVKA II Antigen

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技术背景
Synonyms Vitamin K Absence or antagonist-II and PIVKA‑II
Target Background Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ- carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ- carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ- carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.
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For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.